hcv replication — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11541	HCV-IN-30		Others , HCV Protease
	HCV-IN-30 is an HCV NS5A replication complex inhibitor (IC50s: 901 and 102 nM for genotypes 1a and 1b replicons).		Others , HCV Protease
T11539	HCV-IN-29		HCV Protease
	HCV-IN-29 is a hepatitis C virus (HCV) inhibitor.		HCV Protease
T38237	2′-O-Methylcytidine		Nucleoside Antimetabolite/Analog , HCV Protease
	2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 μM).1It inhibits HCV replication in a replicon assay (IC50= 21.2 μM). 1.Migliaccio, G....		Nucleoside Antimetabolite/Analog , HCV Protease
T9567	Samatasvir	ATOLIHZIXHZSBA-BTSKBWHGSA-N,IDX719	HCV Protease
	Samatasvir (ATOLIHZIXHZSBA-BTSKBWHGSA-N) is a pan-genotypic inhibitor of the HCV non-structural protein 5A.		HCV Protease
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T11281L	FGI-106 tetrahydrochloride		Virus Protease , HCV Protease , Influenza Virus , HIV Protease
	FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective ...
TQ0162	R-1479	4'-Azidocytidine	HCV Protease
	R-1479 (4'-Azidocytidine) is an RdRp inhibitor with an IC50 value of 1.28 μM for HCV RNA replication in the HCV subgenomic replicon system.		HCV Protease
T16088	MK-0608		HCV Protease
	MK-0608 is an orally bioavailable HCV replication inhibitor in vitro(EC50 = 0.3 μM and EC90=1.3 μM in the subgenomic-replicon assay).		HCV Protease
T9331	Bemnifosbuvir hemisulfate	AT-527	HCV Protease , SARS-CoV
	Bemnifosbuvir hemisulfate (AT-527) is a potent inhibitor of HCV virus replication.		HCV Protease , SARS-CoV
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T7607	PSI-6130	R 1656	HCV Protease
	PSI-6130 (R 1656) is a potent and selective HCV NS5B polymerase inhibitor. PSI-6130 inhibits HCV replication with a mean IC50 of 0.6 μM.		HCV Protease
T1822L	Clemizole hydrochloride		HCV Protease , Histamine Receptor
	Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding.		HCV Protease , Histamine Receptor
T12961	Sofosbuvir impurity F	Sofosbuvir 3',5'-Bis-(S)-phosphate	HCV Protease
	Sofosbuvir impurity F (Sofosbuvir 3',5'-Bis-(S)-phosphate) is both a diastereomer of Sofosbuvir and an impurity of Sofosbuvir which is an inhibitor of HCV RNA replication.		HCV Protease
T16710	Mericitabine	R-7128,RG 7128,PSI 6130 diisobutyrate	HCV Protease
	Mericitabine (R-7128) is a nucleoside HCV NS5B polymerase inhibitor. It acts as an RNA chain terminator and prevents the elongation of RNA transcripts during replication.		HCV Protease
T1822	Clemizole		HCV Protease , Histamine Receptor
	Clemizole is an H1 histamine receptor antagonist, can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.		HCV Protease , Histamine Receptor
T4121	Bicyclol	SY801	HBV , Autophagy
	Bicyclol (SY801)(SY 801) is an anti-hepatitis drug. Oral administration of bicyclol normalizes the elevated serum transaminases (ALT, AST) by 50% in chronic viral hepatitis B and C, and also has a certain level of inhibi...		HBV , Autophagy
T19675	SM360320	CL-087,SM 360320,CL 087,1V136,SM-360320,CL087	TLR
	SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for ...		TLR
T9249	ITMN4077		Antiviral
	ITMN4077 has antiviral activity against Hepatitis C virus infected in human HuH7 cells assessed as inhibition of HCV subgenomic replicon replication with an EC50 of 2.131μM.		Antiviral
T3226	Paritaprevir	ABT-450,Veruprevir	HCV Protease
	Paritaprevir (ABT-450) is an orally bioavailable, synthetic acylsulfonamide inhibitor of the hepatitis C virus (HCV) protease complex comprised of non-structural protein 3 and 4A (NS3/NS4A), with potential activity again...		HCV Protease
T12962	Sofosbuvir impurity G		HCV Protease
	Sofosbuvir impurity G is a diastereoisomer of Sofosbuvir.Sofosbuvir is an HCV RNA replication inhibitor, with potent anti-hepatitis C virus activity.		HCV Protease